Journal
NEUROSCIENCE
Volume 140, Issue 3, Pages 1023-1029Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2006.01.015
Keywords
aging; degradation; extrastriate cortex; rhesus monkeys; vision
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Funding
- NIA NIH HHS [R01 AG 17922] Funding Source: Medline
- NATIONAL INSTITUTE ON AGING [R01AG017922] Funding Source: NIH RePORTER
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The receptive field properties of striate cortical (V1) cells degrade in senescent macaque monkeys. We have now carried out extracellular single unit studies of the receptive field properties of cells in extrastriate visual cortex (area V2) in very old rhesus (Macaca mulatta) monkeys. This study provides evidence that both the orientation and direction selectivities of V2 cells in old monkeys degrade significantly. Decreased selectivity is accompanied by increased visually driven and spontaneous responses. As a result, V2 cells in old animals exhibit markedly decreased signal-to-noise ratios. A significant degradation of neural function in extrastriate cortex may underlie the declines in higher order visual function that accompany normal aging. (c) 2006 IBRO. Published by Elsevier Ltd. All rights reserved.
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