Journal
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
Volume 291, Issue 3, Pages H1015-H1026Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpheart.00023.2006
Keywords
cell-cell interaction; extracellular matrix
Funding
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR016434, P20RR016461] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL068038] Funding Source: NIH RePORTER
- NCRR NIH HHS [P-20-RR-16461, P-20-RR-1643401] Funding Source: Medline
- NHLBI NIH HHS [HL-68038] Funding Source: Medline
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Cardiac function is determined by the dynamic interaction of various cell types and the extracellular matrix that composes the heart. This interaction varies with the stage of development and the degree and duration of mechanical, chemical, and electrical signals between the various cell types and the ECM. Understanding how these complex signals interact at the molecular, cellular, and organ levels is critical to understanding the function of the heart under a variety of physiological and pathophysiological conditions. Quantitative approaches, both in vivo and in vitro, are essential to understand the dynamic interaction of mechanical, chemical, and electrical stimuli that govern cardiac function. The fibroblast can thus be a friend in normal function or a foe in pathophysiological conditions.
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