4.5 Article

Antiamoebic activity of iridoids from Morinda morindoides leaves

Journal

PLANTA MEDICA
Volume 72, Issue 8, Pages 751-753

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-2006-931581

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An aqueous decoction (dried extract), an 80% methanolic extract from Morinda morindoides (Rubiaceae) leaves, and five iridoids isolated from the 80% methanolic extract were evaluated in vitro for their activity against Entamoeba histolytica and their cytotoxicity. The aqueous decoction and the 80% methanolic extract exhibited a promising antiamoebic activity with IC50 values of 3.1 +/- 1.7 and 1.7 0.6 pg/mL, respectively. All tested iridoids displayed antiamoebic activity, the most active being epoxygaertneroside (IC50: 1.3 +/- 0.4 mu g/mL) and methoxygaertneroside (IC50: 2.3 +/- 0.7 mu g/mL) followed by gaertneroside, acetylgaertneroside and gaertneric acid with IC50 values of 4.3 +/- 1.8, 5.4 +/- 1.4 and 7.1 +/- 1.4 mu g/mL, respectively. Synergistic effects between the iridoids tested, or with other constituents, may explain the high activity of the extracts. All extracts and iridoids were devoid of any cytotoxic effect against MT-4 cells at the highest test concentration of 250 mu g/mL. These findings support at least in part the traditional use of Morinda morindoides leaves for the treatment of amoebiasis in the Democratic Republic of Congo.

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