Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 4, Issue 5, Pages 787-801Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b518019h
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We present the design, synthesis, and biological activity of three classes of tryptamine derivatives, which are non-planar analogues of the toxic anti-cancer agent fascaplysin. We show these compounds to be selective inhibitors of CDK4 over CDK2, the most active compound 9q has an IC50 for the inhibition of CDK4 of 6 mu M.
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