Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 4, Issue 24, Pages 4526-4532Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b614477b
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We report a simple and high-yielding two-step procedure for the preparation of 8-arylated guanosine mono- and triphosphates (8-aryl GXPs). The key step of our synthesis is the Suzuki - Miyaura coupling of unprotected 8-bromo GMP and 8-bromo GTP with various arylboronic acids in aqueous solution. The 8-bromoguanosine 5'-phosphates required as cross-coupling substrates were prepared from 8-bromoguanosine via an optimised Yoshikawa procedure.
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