Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 4, Issue 5, Pages 860-867Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b516152e
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The total synthesis of alkaloids phenanthroindolizidine 1a, tylophorine 1b, and phenanthroquinolizidine 1c, has been achieved in 46%, 49%, and 42% overall yield, respectively, starting from the corresponding phenanthrene-9-carboxaldehyde. Compound 1c exhibited potent inhibition activity in three human cancer cell lines, with IC50 values ranging from 104 to 130 nM. The structure-activity relations of these alkaloids and some of their synthetic intermediates against the three cell lines were also described.
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