Journal
JOURNAL OF NEUROPHYSIOLOGY
Volume 95, Issue 1, Pages 119-133Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.00467.2005
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Funding
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [R01DE011451, R01DE013810] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS [R01DC001065] Funding Source: NIH RePORTER
- NIDCD NIH HHS [DC-01065] Funding Source: Medline
- NIDCR NIH HHS [DE-13810, DE-11451] Funding Source: Medline
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The classification of rhythmic licking into clusters has proved to be useful for characterizing brain mechanisms that modulate the ingestion of natural rewards (sucrose and water). One cortical area that is responsive to rewarding stimuli is the orbitofrontal cortex (OFC). However, it is not presently known how OFC neurons respond while rodents freely lick for natural rewards and whether these responses are related to the structure of licking clusters. We addressed these issues by showing that temporary inactivation of the OFC decreases the duration and increases the number of clusters and that the activity of OFC neurons changed at precise times before, during, and after the cluster terminates. Furthermore, analysis of the activity of OFC neuronal ensembles showed that they could discriminate cluster onset from termination, predict when a behaving animal will begin a cluster, and distinguish and anticipate between natural rewards. These results provide a new role for the OFC in influencing licking clusters and anticipating specific rewards.
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