Journal
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
Volume 12, Issue 1, Pages 9-12Publisher
CARDEN JENNINGS PUBL CO LTD
DOI: 10.1016/j.bbmt.2005.10.025
Keywords
adoptive transfer; T-cell response
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Animal models and human studies of allogeneic hematopoietic cell transplantation (HCT) demonstrate that immunologic nonidentity between donor and recipient is responsible for a graft versus leukemia (GVL) effect that contributes to complete tumor eradication. A variety of immune cells have been implicated in the GVL effect including NK cells, B cells, and CD4(+) and CD8(+) T cells that recognize minor histocompatibility (H) or leukemia-associated antigens. Here we discuss strategies for employing T cells specific for minor H antigens to augment the GVL effect. (C) 2006 American Society for Blood and Marrow Transplantation.
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