Towards organo-click reactions: development of pharmaceutical ingredients by using direct organocatalytic bio-mimetic reductions

Economic and environmentally friendly bio-mimetic one-pot three and four-component Knoevenagel - hydrogenation ( K - H), five-component Knoevenagel - hydrogenation - alkylation (K - H - A) and six-component Knoevenagel - hydrogenation - alkylation - Huisgen cycloaddition (K - H - A - HC) reactions of aldehydes, CH-acids, o-phenylenediamine, alkyl halides and azides using proline, proline - metal carbonate and proline - metal carbonate - Cu-I-catalysis, respectively have been developed. Many of K - H and K - H - A compounds have direct application in pharmaceutical chemistry.