Journal
JOURNAL OF APPLIED PHYSIOLOGY
Volume 100, Issue 1, Pages 178-185Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.00827.2005
Keywords
KDR; Flt-1; fiber cross-sectional area
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Funding
- NIA NIH HHS [AG-18407, AG-19209, AG-021891] Funding Source: Medline
- NATIONAL INSTITUTE ON AGING [R15AG021891, R15AG018407, R21AG019209] Funding Source: NIH RePORTER
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Recently, we observed that muscle capillarization, vascular endothelial growth factor ( VEGF) protein, and the VEGF mRNA response to acute exercise were lower in aged compared with young women ( Croley AN, Zwetsloot KA, Westerkamp LM, Ryan NA, Pendergast aged men, Hickner RC, Pofahl WE, and Gavin TP. J Appl Physiol 99: 1875 - 1882, 2005). We hypothesized that similar age-related differences in muscle capillarization and VEGF expression would exist between young and aged men. Skeletal muscle biopsies were obtained from the vastus lateralis before and at 4 h after a submaximal exercise bout for the measurement of morphometry, capillarization, VEGF, KDR, and Flt-1 in seven aged ( mean age 65 yr) and eight young ( mean age 21 yr) sedentary men. In aged compared with young men, muscle capillary contacts and capillary-to-fiber perimeter exchange index were lower regardless of fiber type. Muscle VEGF mRNA and protein were lower in aged men both at rest and 4 h postexercise. Exercise increased muscle VEGF mRNA and protein and KDR mRNA independent of age group. There were no effects of exercise or age on muscle Flt-1 mRNA or protein or KDR protein. These results confirm that skeletal muscle capillarization and VEGF expression are lower in aged compared with young men.
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