Journal
NANO LETTERS
Volume 6, Issue 1, Pages 101-104Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl052161c
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R21GM072893] Funding Source: NIH RePORTER
- NIGMS NIH HHS [GM072893] Funding Source: Medline
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Existing DNA nanodevices operate at equilibrium under changes in solution composition. We propose an alternative DNA switch design that can be driven and maintained out of equlibrium, under fixed chemical conditions. Moderate cooling rate after heat denaturation drives the switch to its lowest energy conformation, while rapid cooling (> 100 degrees C/ms) locks the molecule in a unique alternative conformation that is retained over weeks at room temperature. This reversible process is probed using fluorescent energy transfer. DNA switches operating out of equilibrium should be more amenable to nanotechnology applications and scalable integration.
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