Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 4, Issue 22, Pages 4149-4157Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b609143a
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P01GM062566] Funding Source: NIH RePORTER
- NIGMS NIH HHS [GM 62566] Funding Source: Medline
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We describe a large scale synthesis of secramine A. Consistent with its ability to inhibit activation of the small GTPase Cdc42, we find that secramine A inhibits cell spreading, a process previously shown to be Cdc42-dependent.
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