Journal
ENVIRONMENTAL POLLUTION
Volume 143, Issue 2, Pages 278-284Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2005.11.034
Keywords
air pollution; asthma; geographic information systems; biomarker; metallothionein
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Complex interaction between anthropogenic activities, air quality and human health in urban areas, such as in Cracow sustains the need for the development of an interdisciplinary and integrated risk-assessment methodology. In such purpose, we propose a pilot study performed on asthmatics and based on a combined use of a biomarker, such as metallothionein 2A (MT-2A) in the characterization of human exposure to one or a mixture of pollutants and of Geographical Information Systems (G.I.S.) which integrates climatic and urban anthropogenic parameters in the assessment of spatio-temporal dispersion of air pollutants. Considering global incidence of air pollution on asthma and on peripheral blood lymphocytes MT-2A expression should provide a complementary information on biological risks linked to urban anthropogenic activities. Such study would help for the establishment of a sustainable development in urban areas that can maintain the integrity of air quality and preserve human health. (c) 2005 Elsevier Ltd. All rights reserved.
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