Journal
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Volume 841, Issue 1-2, Pages 52-64Publisher
ELSEVIER
DOI: 10.1016/j.jchromb.2006.03.055
Keywords
monolith; solid-phase extraction; silica; polymer; capillary; microchip
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Monolithic materials are finding their place in a variety of fields. While liquid chromatography is the most emphasized use of this new category of porous media, some other just as important applications are eclipsed by the success of monolithic columns. This review article describes all current facets of use of monoliths in preconcentration and solid-phase extraction. In addition to the typical off line use that does not seem to be the main stream application for the monolithic materials, in-line connection of the preconcentration with HPLC, electrochromatography, electrophoresis, enzymatic digestion, as well as its applications in microfluidics are presented. (c) 2006 Elsevier B.V. All rights reserved.
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