Studies on spiroheterocycles, part II: Heterocyclization of the spiro compounds containing cyclohexanone and thiobarbituric acid with different bidentate nucleophilic reagents

The reaction of thiobarbituric acid with different diarylidene ketones 1a - c yields the spiro compounds 2a - c. The diarylidene derivatives 3a - c are synthesized by the condensation of spiro compounds 2a - c with different aldehydes. A series of spiro heterocycles compounds 4a - l, 5a - l, 6a - l, 7a - l, 8a - l, and 9a - l are synthesized from the diarylidene compounds. The structures of the compounds are ascertained from their analytical and spectral data. Some of the compounds are screened for their biological activities.