Journal
SYNTHETIC COMMUNICATIONS
Volume 36, Issue 24, Pages 3713-3721Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10916460600946139
Keywords
catalysis; nucleosides; Suzuki-Miyaura reaction; water
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Reaction conditions for the Suzuki - Miyaura cross-coupling of unprotected halopurine nucleosides with arylboronic acids in aqueous media were investigated. A series of arylated purine nucleosides was prepared in water without an organic cosolvent, using either Pd(PPh3)(4) or Pd(OAc)(2)/TPPTS as the catalyst.
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