Use of 1,1,1,2-tetrafluoroethane (R-134a)-expanded liquids as solvent media for ecoefficient particle design with the DELOS crystallization process

R-134a-expanded liquids have been used as solvent media for the straightforward crystallization of micron-sized crystalline powders using the depressurization of an expanded liquid organic solution (DELOS) procedure. The results, obtained with three different kinds of compounds-aspirin, hexamethylenetetramine, and solvent blue 35-show that R-134-expanded liquids are suitable solvent media for material synthesis and processing at much lower working pressures (<1 MPa) than those required with compressed CO2 (>15 MPa) and even CO2-expanded solvents (approximate to 10 MPa).