Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 70, Issue 1, Pages 22-30Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.70.22
Keywords
Corynebacterium glutamicum; mycolic acid; fatty acid; glutamate overproduction
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Overproduction of glutamate by Corynebacterium glutamicum is induced by biotin limitation or by the supplementation of specific detergents, sublethal amounts of penicillin, or cerulenin. But, it remains unclear why these different treatments, which have different sites of primary action, produce similar effects. In this study, it was found that the cellular content of mycolic acids-characteristic constituents of Coryne-bacterineae that are synthesized from fatty acids and form a cell surface layer-decreased under all conditions that induced glutamate overproduction. Furthermore, short mycolic acids increased under conditions of biotin limitation and cerulenin supplementation. These results suggest that different treatments produce the same effect that causes defects in the mycolic acid layer. This is perhaps one of the key factors in overproduction of glutamate by C. glutamicum.
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