4.3 Article

KF/Al2O3-mediated N-alkylation of amines and nitrogen heterocycles and S-alkylation of thiols

Journal

SYNTHETIC COMMUNICATIONS
Volume 36, Issue 23, Pages 3599-3607

Publisher

TAYLOR & FRANCIS INC
DOI: 10.1080/00397910600943634

Keywords

N-alkylation; S-alkylation; alkyl halides; amines; thiols

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KF/Al2O3 efficiently catalyzes N-alkylation of heterocyclic, primary, and secondary amines and S-alkylation of thiols with a variety of alkyl halides. The N-alkylation and S-alkylation adducts were produced in good to excellent yields and in short times.

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