Journal
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Volume 173, Issue 1, Pages 16-22Publisher
AMER THORACIC SOC
DOI: 10.1164/rccm.200502-235PP
Keywords
chronic obstructive pulmonary disease; genetics; linkage; lung cancer
Categories
Funding
- NATIONAL CANCER INSTITUTE [U01CA076293, P30CA022453, R01CA060691] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA60691, U01 CA76293, P30 CA22453-24, N01-PC-25005] Funding Source: Medline
Ask authors/readers for more resources
Lung cancer continues to be the leading cause of cancer death, and although most lung cancer is attributable to cigarette smoking, underlying genetic susceptibility is suggested by studies demonstrating familial aggregation. The first family linkage study of lung cancer has identified linkage of lung, laryngeal, and pharyngeal cancer in families to a region on chromosome 6q23-25. Because lung cancer and chronic obstructive pulmonary disease (COPD) are known to aggregate in families beyond shared risk associated with smoking, the linkage results are compared and contrasted with results from genomewide linkage and association studies and candidate gene studies searching for genes for lung cancer, lung function, and COPD. Linkage on chromosome 6q to both lung cancer and lung function, and on 12 to lung cancer, COPD, and lung function, together with overlap in candidate genes for these outcomes, suggests that future research into underlying genetic mechanisms of lung disease would benefit from broadening the collection of family history data and better defining the high risk population. As familial risk of lung disease is better defined, referral into screening programs and prevention trials can be better targeted to reach families with both a history of lung cancer and COPD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available