Journal
MICROBIOLOGY-SGM
Volume 152, Issue -, Pages 1601-1607Publisher
MICROBIOLOGY SOC
DOI: 10.1099/mic.0.28658-0
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Funding
- PHS HHS [A145565, A138515] Funding Source: Medline
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A highly conserved cryptic plasmid is present in Chlamydia trachomatis yet naturally occurring plasmid-deficient isolates are very rare. This paper describes the isolation and characterization of a plasmid-deficient strain of C. muridarum, using novobiocin as a curing agent. Plasmid-deficient derivatives of C. muridarum strain Nigg were generated at high efficiencies (4-30%). Phenotypic characterization revealed that the cured derivative was unable to accumulate glycogen within intracytoplasmic inclusions. In addition, this strain formed small plaques at a reduced efficiency compared to the wild-type parent.
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