Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 207, Issue 3, Pages 582-593Publisher
WILEY
DOI: 10.1002/jcp.20538
Keywords
-
Categories
Funding
- NATIONAL CANCER INSTITUTE [R01CA096448, R29CA067189, R01CA067189] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL072691] Funding Source: NIH RePORTER
- NCI NIH HHS [CA67189, CA96448] Funding Source: Medline
- NHLBI NIH HHS [HL72691] Funding Source: Medline
Ask authors/readers for more resources
Converging studies from many investigators indicate that RUNX1 has a critical role in the correct maintenance of essential cellular functions during embryonic development and after birth. The discovery that this gene is also frequently mutated in human leukemia has increased the interest in the role that RUNX1 plays in both normal and transforming pathways. Here, we provide an overview of the many roles of RUNX1 in hematopoietic self-renewal and differentiation and summarize the information that is currently available on the many mechanisms of RUNX1 deregulation in human leukemia.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available