Journal
CANCER RESEARCH
Volume 70, Issue 5, Pages 1749-1752Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-09-3401
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Funding
- Institut Pasteur de Lille, Inserm
- Region Nord Pas de Calais
- Fondation pour la Recherche Medicale
- Agence pour la Recherche sur le Cancer
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Chronic intestinal inflammation has been linked to the development of colorectal cancer. Recent studies suggest that during chronic inflammation, the innate immune system may facilitate colon tumorigenesis in genetically predisposed individuals in response to certain indigenous microorganisms and/or cell remnants. In these individuals, therapeutic approaches that reroute the innate immune system's inflammatory and antimicrobial activities might help prevent colon tumorigenesis and metastasis. Cancer Res; 70(5); 1749-52. (C)2010 AACR.
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