Journal
NATURE PROTOCOLS
Volume 1, Issue 4, Pages 1671-1679Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nprot.2006.275
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Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS048335] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG015490, R01AG018478, R01AG025509, P50AG025711] Funding Source: NIH RePORTER
- NIA NIH HHS [AG15490, AG25509, AG25711, AG18478, R01 AG015490, R01 AG015490-09A1] Funding Source: Medline
- NINDS NIH HHS [NS48335] Funding Source: Medline
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The radial arm water maze (RAWM) contains six swim paths (arms) extending out of an open central area, with an escape platform located at the end of one arm (the goal arm). The goal arm location remains constant for a given mouse. On day 1, mice are trained for 15 trials (spaced over 3 h), with trials alternating between visible and hidden platform. On day 2, mice are trained for 15 trials with the hidden platform. Entry into an incorrect arm is scored as an error. The RAWM has the spatial complexity and performance measurement simplicity of the dry radial arm maze combined with the rapid learning and strong motivation observed in the Morris water maze without requiring foot shock or food deprivation as motivating factors. With two sessions each day, 16 mice can be tested over 2 days.
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