Journal
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
Volume 92, Issue 1, Pages 32-37Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijgo.2005.09.004
Keywords
preeclampsia; cerebrospinal fluid; angiogenic factors; sFlt-1; VEGF; PlGF
Categories
Ask authors/readers for more resources
Objective: Recent data suggest that excess circulating soluble fms-like tyrosine kinase-1 (sFlt-1) may causally relate to preeclampsia. This study investigates the levels of sFlt-1, VEGF, and PIGF in cerebrospinal fluid (CSF) of patients with preeclampsia and normotensive controls. Methods: CSF was collected from preeclamptic patients (n = 15) and controls (n = 7) at the time of spinal anesthesia and assayed for PIGF, sFlt-1, and VEGF (total and free) by specific immunoassays. Results: All sought angiogenic factors were measurable. Levels of free PlGF but not sFlt-1 or VEGF (total or free) were increased in CSF of preeclamptic women. There was no significant difference in the ratios of angiogenic factors in the CSF of women with preeclampsia. There was no correlation between levels of angiogenic factors and CSF cell counts or severity of symptoms. Conclusion: Elevated levels of PIGF in CSF preeclamptic women may promote vascular permeability and contribute to the hypertensive encephalopathy seen in such patients. (c) 2005 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available