Journal
TUMOR BIOLOGY
Volume 27, Issue 6, Pages 334-338Publisher
KARGER
DOI: 10.1159/000096126
Keywords
age; ALDH2; head and neck squamous cell carcinoma; polymorphism
Categories
Ask authors/readers for more resources
Recent molecular epidemiological studies have revealed a possible association of the acetaldehyde dehydrogenase-2 (ALDH2) 1510 G/A (Glu487Lys) polymorphism with various cancers including head and neck squamous cell carcinoma (HNSCC). To further elucidate the significance of this polymorphism in HNSCC development, the relationship between ALDH2 1510 G/A and clinicopathological parameters, cigarette smoking or alcohol intake was evaluated in patients with HNSCC. DNA samples from 192 patients with primary HNSCC and 192 age- and gender-matched healthy controls were genotyped and statistically evaluated. Although there was no significant difference in the genotype distribution of ALDH2 1510 G/A between cases and controls, we found that the frequency of the ALDH2 genotypes with the mutated A (Lys) allele was greater in patients aged ! 66 years than in those aged 6 66 years (p=0.034). This tendency became more evident in patients with the habit of drinking (n=143; p=0.009). The association of ALDH2 1510 G/A with age remained significant after multivariate logistic regression analysis was performed for the patients ( odds ratio for an age interval for 1 year, 0.970; 95% confidence interval, 0.943-0.998). The present data suggest a possible interaction between the ALDH2 1510 G/A polymorphism and age in HNSCC. Copyright (c) 2006 S. Karger AG, Basel
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available