Journal
JOURNAL OF PROTEOME RESEARCH
Volume 5, Issue 1, Pages 54-63Publisher
AMER CHEMICAL SOC
DOI: 10.1021/pr050248t
Keywords
isoniazid; tuberculosis; protein profiling; liquid chromatography; mass spectrometry
Categories
Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U01AI054842] Funding Source: NIH RePORTER
- NIAID NIH HHS [U01 AI054842] Funding Source: Medline
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A new approach for qualitative and quantitative proteomic analysis using capillary liquid chromatography and mass spectrometry to study the protein expression response in mycobacteria following isoniazid treatment is discussed. In keeping with known effects on the fatty acid synthase II pathway, proteins encoded by the kas operon (AcpM, KasA, KasB, Accd6) were significantly overexpressed, as were those involved in iron metabolism and cell division suggesting a complex interplay of metabolic events leading to cell death.
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