Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 97, Issue 1, Pages 71-83Publisher
WILEY
DOI: 10.1002/jcb.20676
Keywords
O-GlcNAc; O-GlcNAc transferase; O-GlcNAcase; diabetes; stress; cell cycle; transcription; signaling; phosphorylation
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O-GlcNAc is all ubiquitous post-translational protein modification consisting of a single N-acetlyglucosamine moiety linked to serine or threonine residues on nuclear and cytoplasmic proteins. Recent work has begun to uncover the functional roles of O-GlcNAc in cellular processes. O-GlcNAc modified proteins are involved in sensing the nutrient status of the surrounding cellular environment and adjusting the activity of cellular proteins accordingly. O-GlcNAc regulates cellular responses to hormones such as insulin, initiates a protective response to stress, modulates a cell's capacity to grow and divide, and regulates gene transcription. This review will focus on recent work involving O-GlcNAc in sensing the environment and regulating signaling cascades.
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