Gamma delta T cell receptors

Gamma delta (gamma delta)T cells are among the least understood components of the immune system. While these cells appear to contribute uniquely to host immune competence, defining their functions in the context of host biology and pathology has been difficult. This is largely because it is unclear what antigens the gamma delta T cell receptor repertoire is directed against. During the past year, there have been noteworthy advances in this area. Their significance in the context of gamma delta T cell biology is discussed.