Journal
ANTIVIRAL RESEARCH
Volume 71, Issue 2-3, Pages 276-281Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.antiviral.2006.04.017
Keywords
L-nucleoside enantiomers; antiviral drugs
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The discovery that some nucleoside analogues endowed with the unnatural L-configuration can possess biological activities has been a significant breakthrough in antiviral chemotherapy. In this regard, lamivudine (3TC) was the first L-nucleoside enantiomer approved against HIV and HBV, and several other L-nucleosides are currently under clinical development as antiviral agents (c) 2006 Elsevier B.V. All rights reserved.
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