Journal
JOURNAL OF MAGNETIC RESONANCE IMAGING
Volume 23, Issue 6, Pages 921-932Publisher
WILEY
DOI: 10.1002/jmri.20579
Keywords
BOLD-fMRI; ASL-fMRI; DWI; probabilistic tractography; EEG; clinical applications; cochlear implant candidates
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Functional magnetic resonance imaging (fMRI) has become a popular research tool, vet its use for diagnostic purposes and actual treatment planning has remained less widespread. The literature yields rather sparse evidence-based data on clinical fMRI applications and accordant decision-making. Notwithstanding. blood oxygenation level dependent (BOLD)- and arterial spin labeling (ASL)-fMRI can be judiciously combined with perfusion measurements, electroencephalographic (EEG) recordings, diffusion-weighted imaging (DWI), and fiber tractographies to assist clinical decisions. In this article we provide an overview of clinical fMRI applications based on illustrative examples. Assessment of cochlear implant candidates by fMRI is covered in some detail, and distinct reference is made to particular challenges imposed by brain tumors, other space-occupying lesions. cortical dysplasias, seizure disorders, and vascular malformations. Specific strategies, merits, and pitfalls of analyzing and interpreting diagnostic fMRI studies in individual patients are highlighted.
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