Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 63, Issue 12, Pages 1331-1354Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-005-5589-y
Keywords
sialic acid; lectin; sialoglycoconjugate; sialic acid-specific lectin; adhesin; infectious disease; immunology
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Sialic acids consist of a family of acidic ninecarbon sugars that are typically located at the terminal positions of a variety of glycoconjugates. Naturally occurring sialic acids show an immense diversity of structure, and this reflects their involvement in a variety of biologically important processes. One such process involves the direct participation of sialic acids in recognition events through specific interactions with lectins, a family of proteins that recognise and bind sugars. This review will present a detailed overview of our current knowledge regarding the occurrence, specificity and function of sialic acid-specific lectins, particularly those that occur in viruses, bacteria and non-vertebrate eukaryotes.
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