Journal
GENES & DEVELOPMENT
Volume 20, Issue 11, Pages 1405-1428Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1424806
Keywords
coregulators; epigenetics; transcription
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A decade of intensive investigation of coactivators and corepressors required for regulated actions of DNA-binding transcription factors has revealed a network of sequentially exchanged cofactor complexes that execute a series of enzymatic modifications required for regulated gene expression. These coregulator complexes possess sensing activities required for interpretation of multiple signaling pathways. In this review, we examine recent progress in understanding the functional consequences of molecular sensor and molecular adaptor actions of corepressor/coactivator complexes in integrating signal-dependent programs of transcriptional responses at the molecular level. This strategy imposes a temporal order for modifying programs of transcriptional regulation in response to the cellular milieu, which is used to mediate developmental/homeostatic and pathological events.
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