Journal
EXPERIMENTAL EYE RESEARCH
Volume 82, Issue 1, Pages 46-54Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exer.2005.05.001
Keywords
HSV-1; cornea; IL-6; angiogenesis; VEGF
Categories
Funding
- NATIONAL EYE INSTITUTE [R01EY015291, P30EY008098] Funding Source: NIH RePORTER
- NEI NIH HHS [EY015291, EY08098, EY05093] Funding Source: Medline
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Following ocular HSV-1 infection, neovascularisation of the avascular cornea is a critical event in the pathogenesis of herpetic stromal keratitis. This present study evaluates the role of proinflammatory cytokines such as IL-6 in corneal angiogenesis following virus infection. Both in vivo and in vitro data indicate that IL-6 produced from virus-infected cells can stimulate noninfected resident corneal cells and other inflammatory cells in a paracrine manner to secrete VEGF, a potent angiogenic factor. Antibody neutralisation of IL-6 resulted in a significant decrease in the number of VEGF producing cells in the cornea. Thus, our results further demonstrate the close relationship between proinflammatory cytokines and VEGF-induced corneal neovascularisation. (C) 2005 Elsevier Ltd. All rights reserved.
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