Journal
EMBO REPORTS
Volume 7, Issue 1, Pages 41-45Publisher
WILEY
DOI: 10.1038/sj.embor.7400598
Keywords
cell signalling; hypoxia inducible factor; oxygen sensing; prolyl hydroxylase domain protein
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Metazoans rapidly respond to changes in oxygen availability by regulating gene expression. The transcription factor hypoxia-inducible-factor (HIF), which controls the expression of several genes, 'senses' the oxygen concentration indirectly through the hydroxylation of two proline residues that earmarks the HIF-alpha subunits for proteasomal degradation. We review the expression, regulation and function of the HIF prolyl hydroxylases or prolyl hydroxylases domain proteins, which are genuine oxygen sensors.
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