Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 348, Issue 1-2, Pages 118-124Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200505260
Keywords
acetals; carbohydrates; fluorine; hexafluoro-2-propanol; protecting groups; solvent effect
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In spite of its low nucleophilicity, hexafluoro-2-propanol easily adds to vinyl ethers, without catalyst, to afford a range of hexafluoroisopropyloxy acetals. This addition reaction also occurred in the presence of a competitive, more nucleophilic alcohol. Kinetic studies showed the importance of hydrogen bond parameters in the rate and course of the reaction.
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