Journal
HELVETICA CHIMICA ACTA
Volume 89, Issue 8, Pages 1610-1622Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/hlca.200690161
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We present the first systematic study of the Pd-catalyzed asymmetric methoxycarbonylation of styrene in the presence of chiral ferrocenyl phosphine ligands. The reaction conditions were optimized, and a screening of different catalyst precursors was performed. A number of 1,1'-bis(phosphino)ferrocenes of the Mandyphos, Josiphos, Walphos, and Taniaphos types were tested in combination with [PdCl2(NCPh)(2)], in the presence of TsOH as the acid source. These systems afforded high enantioselectivities, although the regioselectivity of the reaction was found to be in favor of the (undesired) linear ester. The catalytic system made with the Josiphos ligand 1 gave rise to an enantiomeric excess (ee) of 86%.
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