Journal
NEUROPSYCHOLOGIA
Volume 44, Issue 3, Pages 445-453Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropsychologia.2005.05.015
Keywords
preterm birth; gyrification; MRI; language function; temporal lobe
Funding
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [R01HD031715] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [K02MH001142] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS027116] Funding Source: NIH RePORTER
- NCRR NIH HHS [RR06022] Funding Source: Medline
- NICHD NIH HHS [HD31715] Funding Source: Medline
- NIMH NIH HHS [MH01142] Funding Source: Medline
- NINDS NIH HHS [NS27116] Funding Source: Medline
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Preterm birth often results in significant learning disability, and previous magnetic resonance imaging (MRI) studies of preterm children have demonstrated reduction in overall cortical tissue with particular vulnerability in the temporal lobe. We measured cortical gyrification in 73 preterm and 33 term control children at 8 years of age and correlated these findings with tests of language ability to determine the associations among preterm birth, neurodevelopment and functional outcome. Preterm children demonstrated significantly increased bilateral temporal lobe gyrification index compared to term controls. Left temporal gyrification index was significantly negatively correlated with left temporal lobe gray matter volume as well as reading recognition scores in the preterm group. Cortical development in the temporal lobe appears to be differentially vulnerable to preterm birth. (c) 2005 Elsevier Ltd. All rights reserved.
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