Journal
CARDIOVASCULAR RESEARCH
Volume 69, Issue 1, Pages 36-45Publisher
OXFORD UNIV PRESS
DOI: 10.1016/j.cardiores.2005.09.006
Keywords
lipids receptors; LOX-1; oxidised LDL
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LOX-1, a lectin-like 52-kD receptor for oxidized low-density lipoproteins (ox-LDL), is present primarily on endothelial cells. This receptor is upregulated by ox-LDL itself and by angiotensin 11, endothelin, cytokines, and shear stress, all participants in atherosclerosis. This receptor is upregulated in the arteries of hypertensive, dyslipidemic, and diabetic animals. Upregulation of LOX-1 has been identified in atherosclerotic arteries of several animal species and humans, not only on the endothelial lining, but also in the neovasculature of the atherosclerotic plaque, and this receptor is often co-localized with apoptotic cells. Recent studies show upregulation of LOX-1 in the ischemic-reperfused myocardium. LOX-1 inhibition is associated with attenuation of atherosclerosis and associated ischemic injury. LONA may be a novel, exciting target for drug therapy. (c) 2005 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
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