Journal
ARKIVOC
Volume -, Issue -, Pages 221-226Publisher
ARKAT USA INC
DOI: 10.3998/ark.5550190.0007.b22
Keywords
6-iodo; bromo 3-amino-2-methylquinazolin-4 (3H) -ones; Schiff bases; antibacterial activity
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Treatment of 3-amino-2-methylquinazolin-4(3H)-one with iodine monochloride or bromine in acetic acid affords the corresponding 6-iodo / bromo 3-amino-2-methylquinazolin-4 (3H)-ones in high yields. The notable advantages of this protocol are, no need of catalyst, mild conditions, simple operation and short reaction times with high yields. New potentially active Schiff bases are prepared by condensing these 6-iodo / bromo 3-amino-2-methylquinazolin-4 (3H)-ones with different substituted aryl aldehydes. The bioactivity of the synthesized Schiff bases is studied.
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