Targeted drug delivery for refractory hemorrhagic Crohn disease

Focal gastrointestinal inflammation and hemorrhage is a common problem associated with Crohn disease. The present report describes a case of chronic hemorrhage from an inflamed duodenum that was refractory to all endoscopic and systemic therapies, which was successfully treated with chernoembolization of the pancreaticocluodenal arcade with use of corticosteroids and gelatin sponge. The application of chernoembolization techniques need not be limited to treatment of malignancies.