Journal
NEUROBIOLOGY OF AGING
Volume 27, Issue 1, Pages 38-41Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2004.11.011
Keywords
aging; Alzheimer's disease; attention; amnestic mild cognitive impairment; cerebrospinal fluid; insulin; lumbar puncture; norepinephrine; memory
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Funding
- NATIONAL INSTITUTE ON AGING [R01AG010880, T32AG000258] Funding Source: NIH RePORTER
- NIA NIH HHS [R01 AG10880, T32 AG000258] Funding Source: Medline
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We assessed the effects of induced hyperinsulinemia on plasma and cerebrospinal fluid (CSF) levels of norepinephrine (NE) and on cognition for patients with Alzheimer's disease (AD) and normal older adults. For normal adults, insulin increased plasma and CSF NE levels; also, recall for paraphrased details of a story improved as CSF NE levels increased. Mental control was positively correlated with CSF levels of NE for patients. These findings demonstrate that raising peripheral insulin levels can modulate CNS NE levels and suggest that insulin-stimulated increases in NE may modulate cognitive functions. (C) 2005 Elsevier Inc. All rights reserved.
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