Three new indole alkaloids from the leaves of Kopsia officinalis

Three new indole alkaloids, 11,12-de(methylenedioxy)danuphylline (1), methyl (2 beta,11 beta,12 beta,19 alpha)-6,7-didehydro-8,21-dioxo-11,21-cycloaspidospermidine-2-carboxylate (2), and (2 beta,5 beta)-aspidofractinin-16-ol (3) were isolated from Kopsia officinalis, together with 16 known compounds. Their structures were determined by spectroscopic methods. The isolated known compound (-)-12-methoxykopsinaline displayed antimanic effects in Drosophila, with an IC50 value of 12.5 mu g/ml.