Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 63, Issue 1, Pages 6-11Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-005-5417-4
Keywords
brain serotonin; tryptophan hydroxylase-2 (TPH2); single nucleotide polymorphism (SNP); congenic mice; PC12 cells
Categories
Funding
- NIMH NIH HHS [MH-40159] Funding Source: Medline
- NINDS NIH HHS [NS-19576] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [P30MH040159, P50MH040159] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS019576] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Many neuropsychiatric disorders are considered to be related to the dysregulation of brain serotonergic neurotransmission. Tryptophan hydroxylase-2 (TPH2) is the neuronal-specific enzyme that controls brain serotonin synthesis. There is growing genetic evidence for the possible involvement of TPH2 in serotonin-related neuropsychiatric disorders; however, the degree of genetic variation in TPH2 and, in particular, its possible functional consequences remain unknown. In this short review, we will summarize some recent findings with respect to the functional analysis of TPH2.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available