Journal
ACTA PHARMACOLOGICA SINICA
Volume 28, Issue 9, Pages 1343-1354Publisher
ACTA PHARMACOLOGICA SINICA
DOI: 10.1111/j.1745-7254.2007.00679.x
Keywords
chemoprevention; phytochemical; isothiocyanate; sulforaphane; broccoli
Funding
- NATIONAL CANCER INSTITUTE [R21CA100623, R01CA080962] Funding Source: NIH RePORTER
- NCI NIH HHS [R21 CA100623, R01 CA080962, CA80962, CA100623] Funding Source: Medline
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Sulforaphane (SF) is a phytochemical that displays both anticarcinogenic and anticancer activity. SF modulates many cancer-related events, including susceptibility to carcinogens, cell death, cell cycle, angiogenesis, invasion and metastasis. We review its discovery and development as a cancer chemopreventive agent with the intention of encouraging further research on this important compound and facilitating the identification and development of new phytochemicals for cancer prevention.
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