Journal
MOLECULES
Volume 12, Issue 4, Pages 815-820Publisher
MDPI
DOI: 10.3390/12040815
Keywords
sulfur compound; HDAC; Pleuropterus ciliinervis; tumor cell lines
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A sulfur compound, bis(4-hydroxybenzyl)sulfide (1) was isolated from the root extract of Pleuropterus ciliinervis. Its structure was elucidated using NMR spectroscopic techniques and mass spectrometric analysis. Compound 1 showed potent inhibitory activity in a histone deacetylase (HDAC) enzyme assay. It also exhibited growth inhibitory activity on five human tumor cell lines and more sensitive inhibitory activity on the MDA-MB-231 breast tumor cell line.
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