Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 14, Issue 3, Pages 243-245Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb1204
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM068804] Funding Source: NIH RePORTER
- NIGMS NIH HHS [GM68804] Funding Source: Medline
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Histone methylation is important in regulating chromatin structure and function. In budding yeast, methylation of histone H3 at Lys4 (H3-K4) is associated with active transcription and is enriched at the 5' regions of transcribed genes. Here we identify a novel budding yeast JmjC domain-containing H3-K4 demethylase, Jhd2p, that antagonizes the trimethyl modification state and contributes to regulation of telomeric silencing.
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