Journal
EMBO REPORTS
Volume 8, Issue 3, Pages 241-246Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.embor.7400919
Keywords
cell signalling; membrane traffic; phosphoinositide kinases; phosphoinositide phosphatases; phosphoinositides
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Phosphoinositides (PIs) have long been known to have important roles in cell signalling. During the past decade, it has become clear that these lipids also act as constitutive signals that aid in defining organelle identity, and are short-lived recruiters and regulators of cytoskeletal and membrane dynamics. Recent studies have provided important clues as to how regulated activation of PI-metabolizing enzymes and recruitment of their binding proteins might cooperate in targeting distinct pools of PIs to different cell physiological functions.
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