Journal
CHEMISTRY OF NATURAL COMPOUNDS
Volume 43, Issue 1, Pages 19-23Publisher
SPRINGER
DOI: 10.1007/s10600-007-0055-8
Keywords
coumarins; antioxidants; xanthineoxidase; active oxygen species
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Amides of 5,7-dihydroxy-4-methylcoumaryl-3-ylacetic acid were synthesized by the activated ester method using N-hydroxysuccinimide and diisopropylcarbodiimide or by reaction with N,N-carbonylimidazole. The reactivity of 3- substituted 5,7-dihydroxy-4-methylcoumarins toward 2,2-diphenyl-1-picrylhydrazyl and superoxide radical was analyzed. The effect of the synthesized compounds on xanthineoxidase activity was studied.
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