Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 39, Issue 11, Pages 2012-2030Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2007.03.012
Keywords
CD36; scavenger receptor; atherosclerosis; angiogenesis; inflammation
Categories
Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL070083] Funding Source: NIH RePORTER
- NHLBI NIH HHS [R01 HL070083, R01 HL070083-01] Funding Source: Medline
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CD36 is a broadly expressed membrane glycoprotein that acts as a facilitator of fatty acid uptake, a signaling molecule, and a receptor for a wide range of ligands, including apoptotic cells, modified forms of low density lipoprotein, thrombospondins, fibrillar P-amyloid, components of Gram positive bacterial walls and malaria infected erythrocytes. CD36 expression on macrophages, dendritic and endothelial cells, and in tissues including muscle, heart, and fat, suggest diverse roles, and indeed, this is truly a multifunctional receptor involved in both homeostatic and pathological conditions. Despite an impressive increase in our knowledge of CD36 functions, in depth understanding of the mechanistic aspects of this protein remains elusive. This review focuses on CD36 in cardiovascular disease-what we know, and what we have yet to learn. (C) 2007 Elsevier Ltd. All rights reserved.
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